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Mechanistic studies revealed that AS-IV inhibits JNK signaling pathway activation by downregulating phosphorylated JNK (p-JNK) levels, thereby modulating downstream apoptosis-related molecules, such as reducing the Bax/Bcl-2 ratio and suppressing caspase-3 activation, ultimately blocking the mitochondrial apoptosis pathway

It is common for symptoms to peak about three to five months after the last dose of chemotherapy

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Iron measurement using the Iron Assay Kit For total iron measurement, the Iron Assay Kit (Sigma-Aldrich, MAK472) was used, according to the manufacturers instructions

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