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The metabolites produced by the altered intestinal microorganisms, such as SCFA and ethanol, may affect the bile acid and fat metabolism process in the liver, leading to the accumulation of fat, which, in turn, induces hepatic steatosis and triggers the development of Mets ( Figure 2A )

As nonheme iron-containing dioxygenases, ALOX enzymes oxidize PUFAs in a cell-type-dependent manner

The plates were kept at 80 C until shipment

Effect of non-Steroidal Anti-Inflammatory Drugs and Prostaglandins on the Permeability of the Human Small Intestine