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In an in vivo study, the aqueous fraction of Paullinia cupana seeds was repeatedly administered to rats who were then placed in a T-maze, a model of generalized anxiety and panic disorders, and the guarana was shown to have anxiolytic and panicolytic effects [242]

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Additionally, endothelial cells synthesize several molecules, such as Von Willebrand factor (vWF), tissue factor (TF), prostacyclin (PGI2) and thrombomodulin (TM)

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This multi-pathway approach contributes to its versatility across different tissue types and injury conditions