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Furthermore, upregulating GPX4 expression helped protect hippocampal neurons from ferroptosis in a gerbil cerebral ischemia model [265]

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NguyenAPTTsikaEKellyKLevineNChenXWestABet al

Jun 2012;21(2):157-163

Conversely, JR ducks displayed phenotype-dependent regulation-susceptibles developed hypoferremia with GPX4 upregulation, while resistants maintained hyperferremia and physiological iron in liver/spleen