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Front Pharmacol 12:119

doi:10.1016/s0022-2836(03)00347-4

In light of clinical evidence suggesting elevated glutamate in OCD, summarized above, elevating glial glutamate efflux may not be desirable indeed, this is the opposite of the proposed mechanism of riluzole in enhancing reuptake of extrasynaptic glutamate (Pittenger, Coric et al., 2008)