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They discovered that the combination was especially good at increasing the amount of a specific type of collagen called collagen IV, which is crucial for the connection between the top two layers of our skin

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Esculetin (0.5% w/w) also ameliorates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra pars compacta in mice by preventing nitrosative stress, increasing GSH levels, inhibiting the activation of caspase 3 and preventing neuronal apoptosis (42)

It supplies bioactive forms of four essential B vitamins along with betaine (trimethylglycine or TMG)