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Lower acetyl-CoA availability can limit histone acetylation, repressing the transcription of genes essential for immune function

Urinary concentrations of the -oxidation metabolites of VPA were low, whereas concentrations of -oxidation metabolites were high

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Benefits were more pronounced in studies using 6001,200mg per day over at least eight weeks.2 A 2022 randomized controlled trial in patients with metabolic syndrome found that 600mg of ALA daily for 12 weeks significantly reduced triglyceride levels and total cholesterol compared to placebo.59 However, the study did not observe significant changes in LDL-C or HDL-C