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In these cases, conventional oral creatine monotherapy is largely ineffective due to impaired transport across the bloodbrain barrier, prompting the exploration of alternative delivery methods such as intranasal supplementation and gene-based therapies [78, 79]

The starting dose for severe deficiency is typically 1500mcg (the full dose of the 1ml vial) given daily or on alternate days for 1 to 2 weeks, or until haematological remission is achieved

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Kumar, Rajeev|Hauser, Robert A.|Mostillo, Joseph|Dronamraju, Nalina|Graf, Ana|Merschhemke, Martin|Kenney, Christopher Mavoglurant (AFQ056) in combination with increased levodopa dosages in Parkinson's disease patients International Journal of Neuroscience [00207454]

What are the common side effects, and what should I do if I experience them