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Depending on the specific type of synthetic vitamin B12 used and local medical guidelines, these maintenance injections are typically given once a month or once every 2 to 3 months [6] [2]

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Conversely, the M2 phenotype supports tissue repair and synaptic remodeling following the pro-inflammatory phase through the secretion of anti-inflammatory cytokines [i.e., IL-10 and transforming growth factor-beta (TGF-)]

2 Method This review aims to summarize the mechanism of ferroptosis in the pathogenesis of atherosclerotic comorbid depression and to highlight the research progress on the use of Chinese medicine in treating this condition by targeting ferroptosis

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