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Exploring the iron shuttle hypothesis in chelation therapy: effects of combined deferoxamine and deferiprone treatment in hypertransfused rats with labeled iron stores and in iron-loaded rat heart cells in culture

Another study, involving the pharmacological blocking of endogenous melatonin production in rats, observed an increase in tau hyperphosphorylation

To this end, researchers have developed or screened a range of drugs and compounds capable of inhibiting ferroptosis through various approaches and have validated their neuroprotective effects using various disease models (Table III)