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Lyophilised peptides remain stable for 1224 months when frozen, but any temperature excursion above 8C during shipping or storage initiates irreversible protein denaturation

Additionally, the specific BMP antagonist gremlin induces LOX and LOXL1-4 expression through constitutively active TGF/Smad and inducible MAPK/JNK signaling pathways, suggesting BMPs may at least partially mediate enzymatic collagen crosslinking (Sethi et al ., 2013)