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The defect involves pH-dependent TRPML1-mediated efflux of calcium that activates c-Jun amino-terminal kinase ( JNK)-mediated phosphorylation of dynein intermediate chains, and thereby impedes retrograde motility 19

In contrast, the excitatory gastric response elicited by hindpaw stimulation was governed by the activation of the vagal efferent nerve, which necessitated the involvement of the brain as its reflex center