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Therefore, drugs targeting this metabolic pathway may be more effective in KRAS-mutant CRC

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The days of single-target interventions, such as focusing exclusively on A in AD or dopaminergic neurons in PD, are coming to an end

Systemically administered cuproptosis inducers lack strict tumor targeting and accumulate in liver, kidney, and nervous tissues, causing toxicity ( NDDS enable targeted delivery and controlled release of copper ions, thereby precisely inducing cuproptosis to enhance therapeutic efficacy while minimizing toxicity