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10 , M111.010090 (2011)

[ 8 ] In humans, one study found that DSIP reduced circulating ACTH levels, while another found no effect on CRH-stimulated ACTH and cortisol secretion

When aging disrupts the balance of Nrf2 and NF-B, it can increase ROS/RNS and activate inflammatory signaling pathways, thereby damaging cellular components and leading to cardiac injury (de Almeida et al., 2020)