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In addition, cotreatment of docetaxel-resistant NSCLC with docetaxel plus R162 inhibited cancer cell growth and metastasis both in vitro and in xenograft mouse models, again suggesting that combination therapy with anticancer drugs plus a GLUD1 inhibitor is an effective cancer treatment 23

Despite all the beneficial effects, the detrimental effect of G6PD deficiency are still clear in hemolytic anemia and kernicterus of infancy

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Selenium supplementation can further boost the activity of GPX4 and other antioxidant systems, thereby exerting protective effects (237, 238)

The authors have declared that no competing interest exists