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Treatment effects seem to be most effective in patients with mild to moderate osteoarthritis of the knee

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[DOI] [PubMed] [Google Scholar] 36.Costantini TW, Deree J, Peterson CY, et al

The GnRH receptor is also found in certain cancers, and the reduction in circulating estrogen slows the growth of hormone receptor-positive tumors such as ovarian cancer 117 , prostate cancer 118 , and breast cancer 119,120,121

This reduction in oxidative stress not only protects vascular cells but also slows the progression of atherosclerotic plaque formation