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The available studies indicate that the combined effects of HBOT and NAC are context-dependent

The 2019 European guidelines for management of adult obesity in primary care 36 and the South Asian consensus on MNT in diabesity (CoMeND) 1 give importance to a decrease in WC over weight loss alone, as a decrease in WC is associated with a decrease in visceral fat and its associated cardiometabolic risks

The visualization of the changes in the number of ligandreceptor pairs along the examined timescale for each tissue was implemented using Cytoscape (v3.7.1) 154

2.2.2 Destruction of the ECM in chondrocytes In OA, the excessive production of ROS exerts a dual effect on the ECM, leading to its destruction and inhibiting its synthesis