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Molecules 26(16):4913

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Guo Q, Jin Y, Chen X, Ye X, Shen X, Lin M, Zeng C, Zhou T, Zhang J (2024) NF-B in biology and targeted therapy: new insights and translational implications

Detoxification and Toxicology Research Given glutathiones central role in xenobiotic metabolism, extensive research focuses on detoxification applications: Phase II Metabolism Studies: Investigation of glutathione S-transferase-mediated conjugation reactions Drug Metabolism Research: Analysis of GSH involvement in pharmaceutical compound biotransformation and clearance Hepatotoxicity Studies: Examination of GSH depletion in drug-induced liver injury models (acetaminophen, alcohol) Environmental Toxicology: Research on GSH-mediated protection against environmental toxins, pesticides, and industrial chemicals Heavy Metal Toxicity: Investigation of GSHs role in mercury, cadmium, and arsenic detoxification Chemotherapy Research: Studies examining GSH levels and drug resistance in cancer chemotherapy models Reactive Metabolite Scavenging: Research on GSH conjugation with electrophilic drug metabolites and reactive intermediates Experimental models include hepatocyte cultures, liver perfusion systems, GSH-depleted models, and toxicity paradigms measuring GSH depletion kinetics and conjugate formation

Ann N Y Acad Sci 762:474476 Sorrells S, Sapolsky R (2007) An inflammatory review of glucocorticoid actions in the CNS