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Immediate risks include: Rectal perforation : Forceful insertion or improper technique can tear the rectal or colonic wall, potentially causing peritonitis, sepsis, and requiring emergency surgery

Code availability R code used for data analysis is available via the Open Science Framework at References Jelen L

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This head-to-head comparison examines both peptide injections through the lens of clinical evidence, mechanism of action, safety data, and real-world availability in 2026