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The histidine residue serves as the primary copper-binding site through its imidazole ring, creating a stable square-planar copper(II) complex with the amino terminal and adjacent peptide nitrogen atoms

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This creates a regional pattern that does not resemble the results obtained with any other serotonergic drug using this method. Why This Matters This nigrostriatal focus is mechanistically intriguing because these regions are heavily involved in motor control, reward processing, and motivation