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After being consumed by endogenous cells and reversing their pathogenic changes, natural or synthetic EXOs interacting with them may offer therapeutic benefits (Si et al., 2023)

Although gut bacteria have been extensively studied, intestinal fungi remain relatively under-explored, despite accounting for about 0.1% of the gut microbiota 7

Shih AY, Li P, Murphy TH (2005) A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo