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doi: 10.4137/JCD.S11038 35 HuangHTohmeSAl-KhafajiABTaiSLoughranPChenLet al

Thiol supplementation inhibits metalloproteinase activity independent of glutathione status

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The study demonstrated that electrical stimulation of the VECM significantly promoted the proliferation and migration of hUC-MSCs, enhancing the repair and regeneration of pelvic floor muscles

However, in hypoxic environments, VHL cannot mediate the ubiquitination of HIF-1 due to the lack of prolyl hydroxylase domain (PHD) proteins to multi-ubiquitinate or hydroxylate proline residues, resulting in metabolic changes (115)