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Description

Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway

By amplifying HGF signalling at c-Met it switches on the intracellular PI3K/Akt and MAPK/ERK cascades precisely those that govern synaptogenesis, neuroplasticity and neuronal survival

Targeted inhibition of glutaminolysis with the Gls1 inhibitor CB-839 and BPTES, and genetic silencing by Gls1 short interfering (si)RNA, only reduced the expression of collagens, but not that of FN or -SMA