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Accordingly, treatment with the proteasome inhibitor MG132 increased the nuclear accumulation of proIGF-1Eb and proIGF-1Ec, while their cytoplasmic level remained undetectable (Fig

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This is where careful preformulation drug characterization is needed in order to fully understand and predict the nature of niclosamides solid forms, its resulting solubility in aqueous media, and hence its bioavailability, in (any) dosage form