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A key randomized, double-blind, placebo-controlled crossover trial revealed that NR supplementation (1000 mg daily) for 6 weeks increased blood cellular NAD+ concentrations by approximately 60% compared to placebo [4]

They further transplant Og-NSCs into 6-OHDA-lesioned hemi-parkinsonian rats to testify their therapeutic effect, the results showed reproducible behavioral restoration and mDA neuron engraftment in PD animals transplanted with Og-NSCs