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Sheffield-Moore M, Wiktorowicz JE, Soman KV, Danesi CP, Kinsky MP, Dillon EL, Randolph KM, Casperson SL, Gore DC, Horstman AM, Lynch JP, Doucet BM, Mettler JA, Ryder JW, Ploutz-Snyder LL, Hsu JW, Jahoor F, Jennings K, White GR, McCammon SD, Durham WJ

Chrono-optimized and convergence-ready therapeutics A comprehensive approach to MRIS therapy integrates biomarker-driven patient stratification, circadian-informed treatment timing, and the engineering of peripheral-central metabolic crosstalk to enhance stroke recovery

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As a major energy source alongside glucose/glutamine, FAO generates twice the ATP of carbohydrate oxidation through cyclic -oxidation, which shortens fatty acids by two carbons per round, yielding acetyl-CoA (for the TCA cycle) and NADH/FADH 2 (for the ETC) (117)

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