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There were several flaws in these studies such as being-underpowered or not having well-designed (Kenefick et al., 2002

11 Prior to 1976, an era with no carbidopa administration, irreversible dyskinesias were not reported

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FEBS Open Bio 2:119128 Singh PP et al (2011) Molecular chemotherapy and chemotherapy: a new front against late-stage hormone-refractory prostate cancer

Moreover, animal experiments allow researchers to investigate the interactions between apical lesions and systemic conditions, such as cardiovascular diseases (Brilhante Wolle et al., 2012) and diabetes (Prieto et al., 2017)