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Description

High discontinuation rates due to side effects for medications like semaglutide and liraglutide can be as high as 7% within the first year

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Despite the number and importance of such enzymes to cellular metabolism, few studies have been conducted to better understand the effects of MTX on cellular metabolic homeostasis or find metabolic fragilities that could be exploited clinically

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As discussed previously, most studies regarding tumor amino acid metabolism focus on the regulatory mechanism, which contributes to tumor growth (as an essential nutrition, energy source, or raw materials), epigenetic modification, tumor immunity, and ferroptosis

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also reported that Paclitaxel exposure induces ROS production, as H 2 O 2 accumulation showed to be an early and crucial step in paclitaxel cytotoxicity [32]

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