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Selenium-GPX4 axis protects follicular helper T cells from ferroptosis

Excessive absorption or an imbalance of iron circulation can easily lead to iron overload, which will contribute to oxidative damage and even cell death due to irons ability to accept and donate electrons ( Most mammalian cells uptake iron (Fe 2+ ) mainly in two ways: intestinal absorption and senescent erythrocyte degradation

B1a b cells require autophagy for metabolic homeostasis and self-renewal

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Methods Following stabilization on 12/3 mg/day of sublingual buprenorphine/naloxone for 7 days, participants with moderate-to-severe OUD were randomized to receive a single 300-mg BUP-XR injection in the upper arm, thigh, buttocks, or abdomen (reference)