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EBI mechanisms, including endothelial dysfunction, bloodbrain barrier disruption, cerebral edema, neuro-inflammation, cortical spreading depolarizations, and oxidative damage, trigger cell death and apoptosis, setting the stage for DCI development in later clinical phases

There continues to be clear evidence that people under 18 are particularly vulnerable to alcohol-related harms, and the one guideline for all adolescents gives a clear message that is in line with the current evidence

doi:10.2147/JMDH.S306350 41 Sun Y, Zhu S, Li S, Liu H

PloS ONE 4:e4345

Brand, S., Beck, J., Kalak, N., Gerber, M., Kirov, R., Phse, U., Hatzinger, M., & Holsboer-Trachsler, E