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Acknowledgements The authors appreciate and thank the efforts of the Center for the Development of Clinical Researches of the Educational and Therapeutic Research Complex of Birjand University of Medical Sciences

Blood ammonium levels in liver disease and hepatic coma

Furthermore, in an intracerebral hemorrhage (ICH) model, neural stem cell secretions inhibited hemin-induced ferroptosis and cerebral edema via the Nrf2 pathway, with the key component HSPE1 protein potentially mediating this protective effect [133]

Regulation of Vitamin Metabolism Vitamin metabolism is tightly regulated through feedback mechanisms and hormonal control to ensure physiological balance

LDN works primarily by temporarily blocking opioid receptors, specifically the OGF-OGFr axis, which plays a role in the release of endorphins and enkephalins