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When the researchers blocked ferroptosis in aged mice, both oocyte number and quality improved ( Hu et al., FASEB Journal , 2025 )

CTLA4 gene polymorphisms (+49A/G, CT60 A/G) are not linked to disease susceptibility, but experimental models show that CTLA4 blockade reduces ectopic lesion growth by inhibiting Treg-derived IL-10 and TGF- ( 2.2.3 Autoimmune overlaps Endometriosis exhibits autoimmune-like features, including autoantibodies to endometrial antigens and polyclonal B-cell activation ( vs

Bifidobacterium and Lactobacillus genera are the most common strains and potential sources of probiotics, and some of these organisms have powerful anti-inflammatory properties (225)

On the one side, p53 promotes the expression of SAT1 (Qiu et al., 2020), and then increased SAT1 cooperates with ROS to lead to lipid peroxidation (Murphy 2016), further oxidizes PUFAs, and finally causes ferroptosis

In humans, a common deletion variant of the GSTM1 gene, the GSTM1 null allele ( GSTM1(0) ), results in decreased or absent GSTM1 enzymatic activity and is associated with higher levels of oxidative stress