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Although the mechanism(s) underlying NASH progression remain to be fully elucidated, accumulating evidence suggests that both oxidative stress and the pro-inflammatory cytokine tumor necrosis factor- (TNF) are critical contributors in this process 5

Seek immediate medical attention (call 999 or attend A&E) if you develop : Signs of severe dehydration: dizziness, confusion, reduced urine output despite drinking fluids, rapid heartbeat Symptoms of diabetic ketoacidosis: excessive thirst, frequent urination, nausea, vomiting, abdominal pain, fruity-smelling breath, confusion (Note: GLP-1 medications do not cause DKA, but it can occur in type 1 diabetes or ketosis-prone type 2 diabetes, especially during illness) Severe flank pain with fever: may indicate pyelonephritis (kidney infection) If you experience persistent vomiting or diarrhoea from GLP-1 therapy and cannot maintain adequate fluid intake, seek urgent medical advice as there is a risk of dehydration and acute kidney injury

The team is also working to better understand other aspects of the CNS including neurodegenerationthe loss of neuron function

Ipamorelin is versatile and relevant to many experimental models

Spring LK, Krakowski AC, Alam M, et al