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However, a definitive antibody-mediated mechanism of enhancement has not been documented 32 , and models have also identified Th2-skewing of the T cell response and lung eosinophilia with challenge after FI-RSV, raising the possibility that T cells contribute to vaccine-induced enhancement of RSV disease 31,33

The SEC also proposes to include a five-year rolling window, so that noncompliance that occurred more than five years before the commencement of a Rule 506 offering would not trigger disqualification, even if the required Form D filings had not been made