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A single administration of 8 at 42 d.p.i (200 mg/kg i.p.) resulted in a 19% and 7% decrease in worm and egg burdens, respectively

doi: 10.1080/07391102.2020.1835717 303 EberleRJOlivierDSPaccaCCAvillaCMSNogueiraMLAmaralMSet al

Nat Genet 1998

Standardized evaluation frameworks for redox responsiveness, degradation kinetics, and toxicity remain underdeveloped

Notably, addition of hemin or pyruvate, a source for NAD+ did not impact these growth phenotypes, suggesting that amelioration of heme defect or respiration inhibition is not sufficient to overcome anti-proliferative effects of mitochondrial GSH depletion (Extended Data Fig