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Growth factors play a major role in initiating the angiogenesis process and several drugs act on these specific growth factors directly or indirectly which can be repurposed to activate angiogenesis and accelerate the healing of different types of wounds (burns, diabetic ulcers, and trauma wounds)

44,45 For morphology, the endothelial cells in the BBB are fastened by both tight junctions and adherens junctions, resulting in distinct lumenal and abluminal membrane compartments

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Kisspeptin can raise luteinizing hormone (LH) and testosterone, which may boost spermatogenesis in men with certain hypogonadotropic conditions