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Subcutaneous administration at 50mg produces approximately 4050% NNMT enzyme inhibition, while 100mg achieves 6075% inhibition

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10.3390/bioengineering7010026 22 BalkeJ.VolzP.NeumannF.BrodwolfR.WolfA.PischonH.et al (2018)

Another option is to look for hyaluronic acid, a molecule that can hold 1,000 times its weight in water, in the roll call of skincare ingredients on the back of your eye serum or cream