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66 In contrast, pharmacologic inhibition of FAO with etomoxir or ranolazine inhibited cancer cell proliferation and sensitized human leukemia cells to apoptosis induced by ABT-737, a molecule that released proapoptotic Bcl-2 proteins such as Bak from antiapoptotic family members, suggesting that CTP1 can antagonize Bcl-2-induced apoptosis

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Together, these result in increased bilirubin load in the blood circulation and in liver cells of an infant

In animal studies, BPC-157 has shown no adverse effects even at doses a thousand times higher than typical human doses, and its LD50, the dose that would kill 50% of animals, is unknown, making it challenging to become FDA-approved 2m6s

however, these findings have not resulted in the development of efficacious drug therapy