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10.1007/s10404-019-2261-7 79 ShinH

During the transfer of electrons through a pathway, incomplete reduction of oxygen can result in the production of highly damaging and reactive ROS, such as hydroxyl radical, hydrogen peroxide, singlet oxygen and superoxide radicals The toxicity of superoxide radicals can be diminished with the help of metalloenzyme SOD which catalyzes the reduction of O 2 - to O 2 and H 2 O 2

By enhancing endogenous melatonin production, DSIP optimizes the sleep cycle without the need for supplements, making it particularly valuable in the management of insomnia and other sleep disorders

The starting resin used for the synthesis was 21.75g (4-((2,4 -dimethoxyphenyl)-(Fmoc-amino)- methyl)-phenoxy resin (Rink resin) with a substitution capacity of 0.55 mmol/g

Future directions should focus on reprogramming the immunosuppressive TME, enhancing T cell infiltration and function, and developing next-generation immunotherapies