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Preclinical models demonstrate 6080% tumor growth inhibition in KRAS-mutated NSCLC with minimal systemic toxicity, underscoring the therapeutic window created by tumor-selective copper accumulation [126]

[DOI] [PMC free article] [PubMed] [Google Scholar] 183.Arrieta M.-C., Stiemsma L.T., Dimitriu P.A., Thorson L., Russell S., Yurist-Doutsch S., Kuzeljevic B., Gold M.J., Britton H.M., Lefebvre D.L., et al