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Because the CD40 molecule was present on the basal keratinocytes while the neighboring CD4+ T cells expressed CD40L, it was suggested that the CD40-CD40-L system might be involved in the cutaneous manifestation of DM, probably via the upregulation of cytokines and chemokines, in a pattern similar to that described for the muscle (127)

doi: 10.3389/fcell.2016.00016 Received 29 November 2015 Accepted 22 February 2016 Published 23 March 2016 Volume 4 - 2016 Edited by Gaetano Santulli, Columbia University in the City of New York, USA Reviewed by Yves Combarnous, Centre National de la Recherche Scientifique, France

These antigens were observed at molecular weights of approximately 70 and 35 kDa using SDS-PAGE and immunoblotting techniques [64]

Ultimately, this impairment in the cellular antioxidant defense results in an accumulation of lipid ROS, with the subsequent induction of ferroptosis

Curr Mol Med (2014) 14(9):113954.10.2174/1566524014666141015151749 24 JakaitisBMDenningPW