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A reasonable structured approach is a defined 12 week trial with measurable endpoints, followed by a 4 to 8 week break, and a decision about continuation based on results during the active phase

If Cosmetic Irritation Occurs Reduce cosmetic application frequency Lower formulation concentration Discontinue cosmetic use if irritation persists Cosmetic Application Considerations Patch testing is recommended before larger cosmetic application areas Avoid direct contact with eyes Avoid application to broken, compromised, or irritated skin Lower introductory concentrations are commonly preferred for sensitive-skin formulations For Cosmetic Formulation and Research Use Only Not for injection or human consumption

Derived from milk, lactic acid belongs to a class of anti-aging ingredients called alpha-hydroxy acids (AHAs)

10.1002/adfm.202001648 39 LiangK.SunH.YangZ.YuH.ShenJ.WangX.et al (2021)

Vascular endothelial growth factor (VEGF) is a major factor in embryonic development and regulation of physiological angiogenesis for reproductive function