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This microbiome-driven drug reactivation has been associated with severe gastrointestinal side effects including diarrhea, mucosal irritation, and anorexia, as reported by Wallace et al

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[0048] In some embodiments, provided herein is a method for treatment of a mitochondrial ATP deficit disorder, comprising: administering to a patient in need thereof, a composition comprising: (a) a cannabinoid

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