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[73] [74] [75] It is synthesized by some bacteria in the gut microbiota in humans and other animals, but it has long been thought that humans cannot absorb this as it is made in the colon, downstream from the small intestine, where the absorption of most nutrients occurs

Subcutaneous Vitamin B12 Injections for At-Home Use Subcutaneous vitamin B12 injections are a practical option for patients who require ongoing or long-term supplementation

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Eur Neurol 58:9699 Tyagi N et al (2005) Mechanisms of homocysteine-induced oxidative stress

B12 shots deliver a concentrated amount of cobalamin, a water-soluble vitamin essential for red blood cell formation, neurological function, and DNA synthesis, as detailed in the NIH fact sheet on vitamin B12