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Epub 2021 Nov 12

Algorithms based either on a selection of biomarkers measured sequentially or, multiple biomarkers analyzed simultaneously and then combined into a single diagnostic indicator, are both approaches that are used to circumvent the inherent limitations of each individual biomarker

Multi-omic profiling revealed a coordinated reprogramming of epididymal white adipose tissue, characterized by suppressed lipogenesis, enhanced fatty acid oxidation and mitochondrial function, restored peroxisomal activity, and downregulated inflammatory/fibrotic pathways while promoting angiogenic/reparative signaling