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A null polymorphism in NQO1 15,16 has been associated with an increased risk of complications related to metabolic syndrome 17,18 and NQO1-null mice develop insulin resistance resulting in a T2D-like phenotype 19

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Davis et al., 2023) casecontrol studies may have been subject to selection bias because of low participation rates, if those who chose to participate varied from the source population in terms of sweetener use