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At the guideline level: A 2023 Canadian clinical guideline raised concerns that SSRIs may not reliably improve depression in some AUD populations and may worsen alcohol outcomes in certain individuals, recommending caution with SSRIs in that context

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Since the study of LLPS and MLOs/BCs began after the IDP concept was generally accepted, a thorough consideration of this very important point is outside the scopes of this historical perspective

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