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Nature 542 , 335339 (2017)

Some patients report temporary fatigue, headache, flushing, joint aches, or increased hunger

Heme binding protein genes (39 genes out of the studied 121 genes) were also enriched in the upregulated gene set (Additional file 2), however substantial transcriptional changes in the case of heme biosynthesis, Fe-S cluster assembly or Fe-S cluster protein genes were not observed (Additional file 2)