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however, they were seen when administered in conjunction with testosterone at high doses (Taaffe et al., 2001

(2010) 54:S4252

There is substantial evidence that insulin/IGF-1 signaling stimulates the expansion of Tregs and increases their immunosuppressive activity [28, 34]

Among the first IGF-1R pathway targeted agents were monoclonal antibodies that block receptor-ligand interactions and thus activation of the downstream signaling pathways