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Box A: Diversity of GPCR ligands Neurotransmitters norepinephrine adenosine histamine serotonin dopamine cannabinoids opiates acetylcholine GABA glutamate Peptide hormones endothelin glucagon angiotensin II GSH, FSH, CRH GnRH, ACTH Tastants, oderants, light Session Learning Objectives Learning objective 1

It is important to highlight the variability of clinical data

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Metformin induces oxidative stress in white adipocytes and raises uncoupling protein 2 levels

561 At the end of 1 year, DEXA measurements of BMD had improved slightly in the low-prednisone group versus the high-prednisone group, and the inter-group difference was statistically significant (d = 1.409, 95% CI, 0.92 to 1.02, Hedges d test for standard effect sizes)